Clinical and Observational Trials
-
Principal Investigator:
Uma M. Reddy, MD, MPH
This research study is being done to understand how CPAP for sleep apnea may affect hypertensive disorders of pregnancy and other complications of pregnancy such as gestational diabetes. The purpose of the home sleep test is to find women with sleep apnea. Sleep apnea is when you have one or more pauses in breathing or shallow breaths while you sleep. Studies have shown that women with sleep apnea have an increased risk of high blood pressure and diabetes during pregnancy. If the test shows that you have sleep apnea in the mild to moderate range you will be eligible for a research study to...
-
Principal Investigator:
Jason D. Wright, MD
The purpose of this study is to collect and store donated blood samples and associated medical data from participating subjects to help develop an ovarian cancer blood test and for potential research into other gynecological diseases.
-
Principal Investigator:
Jason D. Wright, MD
The goal of this clinical research study is to compare the outcomes of minimally invasive surgery (the investigational surgery) to laparotomy (the current standard of care) in women with Epithelial Ovarian Cancer (EOC) who receive chemotherapy before and after surgery. Researchers want to learn if one surgery can prevent the disease from returning for longer and/or improve your quality of life after surgery. Both the minimally invasive surgery and laparotomy procedures in this study are performed using FDA-approved and commercially available methods. It is considered investigational to...
-
Principal Investigator:
S. Zev Williams, MD, PhD
Researchers at Columbia are looking into possible viral causes of stillbirth or late-term miscarriages in patients. We are looking for people who have recently had a late-term pregnancy loss (within the past week). Participation in this research involves a one-time blood draw. Participants will receive $50.
-
Principal Investigator:
Jason D. Wright, MD
The purpose of the study is to compare how well Rina-S works against ovarian cancer, primary peritoneal cancer, or fallopian tube cancer compared to chemotherapy drugs that are already approved and used for your type of cancer. You have an equal (50:50) chance of getting Rina-S or an approved chemotherapy agent as treatment in this study. Rina-S is not approved by the United States Food and Drug Administration (FDA) because it is still undergoing clinical trials. Rina-S is a type of drug called an antibody-drug conjugate, or "ADC". An antibody-drug conjugate (ADC) is a cancer treatment that...
-
Principal Investigator:
Jason D. Wright, MD
The purpose of this research study is to learn if sacituzumab govitecan (also called SG) can improve lifespan and delay the growth or spread of the disease in participants with endometrial cancer when compared to chemotherapy (doxorubicin or paclitaxel). Sacituzumab govitecan is a type of drug called an antibody-drug conjugate. An antibody-drug conjugate (ADC) is a cancer treatment that combines a monoclonal antibody (mAb) with a drug to deliver chemotherapy directly to cancer cells. Antibodies are proteins normally made by the immune system. The antibody part attaches to a certain type of...
-
Principal Investigator:
Jason D. Wright, MD
This is a research study for patients that have uterine or ovarian, fallopian tube or primary peritoneal cancer that has come back after the last round of treatment, and whose tumor has tested positive for folate receptor-alpha (FR). An experimental study drug called IMGN151 is being studied as a possible study treatment for endometrial, ovarian, fallopian tube or primary peritoneal cancer. This study is the first time IMGN151 is being given to humans to be tested as a possible treatment for cancer. The purposes of this study are: To determine if IMGN151 an experimental drug made by the...
-
Principal Investigator:
Noelia M. Zork, MD
Women will be enrolled at or prior to prenatal visit at 34-40 weeks gestation with follow-up visits within 48 hours of delivery, and 6 and 12 months postpartum among the mother and infant. Maternal and infant measurements will be conducted at each visit. The purpose of the study is to estimate cardiovascular disease risk in healthy and medically complicated pregnant women and their infants 840 mother-infant dyads.
-
Principal Investigator:
Jason D. Wright, MD
The purpose of this clinical research study is to develop a sample collection method that is less invasive than current endometrial sampling methods (uterine sample collection) and develop a diagnostic test from these samples which is as informative in diagnosing the absence of endometrial (uterine) cancer as currently available methods.
-
Principal Investigator:
S. Zev Williams, MD, PhD
Researchers at Columbia are looking at the changes that happen in the placenta when people become pregnant. Participation in this study involves a blood draw at three time points. Participants will be paid $50 at each time point. Participants who complete all three time points will receive bonus compensation.
Pages
